Capturing residual beta cell function in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial
BACKGROUND Recent evidence suggests that the lipid-lowering agent atorvastatin is also a potent immunomodulator. The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes. METHODS AND FINDINGS The randomised placebo-controlled Diabetes and Atorvastatin (DIATOR) Trial included 89 patients with newl...
متن کاملResidual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season
BACKGROUND There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. METHODS In 2005, a national study, the Better Diabetes Diagnosis, was started to classify...
متن کاملRandomised prospective study for the effect of therapy on residual beta cell function in type-1 diabetes mellitus [ISRCTN70703138]
BACKGROUND: Newly diagnosed insulin-dependent diabetes mellitus is characterised by a temporary recovery of endogeneous insulin ("remission") after the beginning of medical treatment with subcutaneous insulin injections. Although most diabetologists think, that insulin reserve is related to reduced occurrence of diabetic long-term complications, such as eye, nerve and kidney disease, there is o...
متن کاملIslet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years.
AIMS To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. METHODS T1D children (n=260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimu...
متن کاملBeta-Cell Function and Failure in Type 2 Diabetes
The main role of beta-cell is to synthesize and secrete insulin in order to maintain circulating glucose levels within physiological range. Although there exist several triggers of insulin secretion like nutrients (amino acids such as leucine, glutamine in combination with leucine, nonesterified fatty acid), hormones, neurotransmitters and drugs (sulfonylurea, glinides), glucose represents the ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2018
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-018-4768-y